Introduction to Bioinformatics - Lecture 13

Today, statistical sampling methods were considered. Here are the topics:

• Statistical mechanics,
• canonical and micro-canonical ensemble,
• observables and partition function,
• molecular dynamics simulations (verlet and velocity verlet algorithm),
• consideration of time step,
• improvement of simulation (cutoff, distance, and multipole schemes),
• standard Monte Carlo method,
• calculation of partition function,
• importance sampling,
• sampling of protein structures.